Ontology highlight
ABSTRACT:
SUBMITTER: Brown AC
PROVIDER: S-EPMC3607044 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Brown Aaron C AC Muthukrishnan Sree Deepthi SD Guay Justin A JA Adams Derek C DC Schafer Dillon A DA Fetting Jennifer L JL Oxburgh Leif L
Proceedings of the National Academy of Sciences of the United States of America 20130304 12
Embryonic nephron progenitor cells are segregated in molecularly distinct compartments of unknown function. Our study reveals an integral role for bone morphogenetic protein-SMAD in promoting transition of progenitors from the primitive Cbp/p300-interacting transactivator 1 expressing (CITED1+) compartment to the uniquely sine oculis-related homeobox 2 expressing (SIX2-only) compartment where they become inducible by wingless-type mouse mammary tumor virus integration site family member (WNT)/β- ...[more]