Ontology highlight
ABSTRACT:
SUBMITTER: Balana B
PROVIDER: S-EPMC3607560 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130325 3
G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putative Ras-association (RA) domain with unknown function. Deleting the RA domain in SNX27b (SNX27b-ΔRA) prevents the down-regulation of GIRK2c/GIRK3 channels. Similarly, a point mutation (K305A) in the RA domain disrupts regulation of GIRK2c/GIRK3 chann ...[more]