Ontology highlight
ABSTRACT:
SUBMITTER: Manoli I
PROVIDER: S-EPMC3608108 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Manoli Irini I Kwan Justin Y JY Wang Qian Q Rushing Elisabeth J EJ Tsokos Maria M Arai Andrew E AE Burch Warner M WM Dispenzieri Angela A McPherron Alexandra C AC Gahl William A WA
Molecular genetics and metabolism 20130204 4
Amyloid myopathy associated with a plasma cell dyscrasia is a rare cause of muscle hypertrophy. It can be a challenging diagnosis, since pathological findings are often elusive. In addition, the mechanism by which immunoglobulin light-chain deposition stimulates muscle overgrowth remains poorly understood. We present a 53-year old female with a 10-year history of progressive generalized muscle overgrowth. Congo-red staining and immunohistochemistry revealed perivascular lambda light chain amyloi ...[more]