Ontology highlight
ABSTRACT:
SUBMITTER: Giustiniano M
PROVIDER: S-EPMC3608355 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Giustiniano Mariateresa M Tortorella Paolo P Agamennone Mariangela M Di Pizio Antonella A Rossello Armando A Nuti Elisa E Gomez-Monterrey Isabel I Novellino Ettore E Campiglia Pietro P Vernieri Ermelinda E Sala Marina M Bertamino Alessia A Carotenuto Alfonso A
Journal of amino acids 20130310
A number of matrix metalloproteinases (MMPs) are important medicinal targets for conditions ranging from rheumatoid arthritis to cardiomyopathy, periodontal disease, liver cirrhosis, multiple sclerosis, and cancer invasion and metastasis, where they showed to have a dual role, inhibiting or promoting important processes involved in the pathology. MMPs contain a zinc (II) ion in the protein active site. Small-molecule inhibitors of these metalloproteins are designed to bind directly to the active ...[more]