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N ? -acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors.

ABSTRACT: HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from N ? -acetyl lysine. In the current study, we raised a novel design, which concerns N ? -acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.

SUBMITTER: Wang F

PROVIDER: S-EPMC6599804 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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N ɛ -acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors.

Wang Fang F Wang Chun C Wang Jie J Zou Yefang Y Chen Xiaoxue X Liu Ting T Li Yan Y Zhao Yonglong Y Li Yongjun Y He Bin B

Royal Society open science 20190605 6

HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from N ɛ -acetyl lysine. In the current study, we raised a novel design, which concerns N ɛ -acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors. ...[more]

PMID: 31312496

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