Ontology highlight
ABSTRACT:
SUBMITTER: Brazdova M
PROVIDER: S-EPMC3608670 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Brázdová Marie M Navrátilová Lucie L Tichý Vlastimil V Němcová Kateřina K Lexa Matej M Hrstka Roman R Pečinka Petr P Adámik Matej M Vojtesek Borivoj B Paleček Emil E Deppert Wolfgang W Fojta Miroslav M
PloS one 20130326 3
Hot spot mutant p53 (mutp53) proteins exert oncogenic gain-of-function activities. Binding of mutp53 to DNA is assumed to be involved in mutp53-mediated repression or activation of several mutp53 target genes. To investigate the importance of DNA topology on mutp53-DNA recognition in vitro and in cells, we analyzed the interaction of seven hot spot mutp53 proteins with topologically different DNA substrates (supercoiled, linear and relaxed) containing and/or lacking mutp53 binding sites (mutp53B ...[more]