Ontology highlight
ABSTRACT:
SUBMITTER: Gohler T
PROVIDER: S-EPMC549414 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Göhler Thomas T Jäger Stefan S Warnecke Gabriele G Yasuda Hideyo H Kim Ella E Deppert Wolfgang W
Nucleic acids research 20050218 3
Despite the loss of sequence-specific DNA binding, mutant p53 (mutp53) proteins can induce or repress transcription of mutp53-specific target genes. To date, the molecular basis for transcriptional modulation by mutp53 is not understood, but increasing evidence points to the possibility that specific interactions of mutp53 with DNA play an important role. So far, the lack of a common denominator for mutp53 DNA binding, i.e. the existence of common sequence elements, has hampered further characte ...[more]