A common mode of recognition for methylated CpG.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3608759 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
A common mode of recognition for methylated CpG.
Liu Yiwei Y Zhang Xing X Blumenthal Robert M RM Cheng Xiaodong X
Trends in biochemical sciences 20130123 4
Much is known about vertebrate DNA methylation, however it is not known how methylated CpG within particular sequences is recognized. Two recent structures of C2H2 zinc finger (ZnF) proteins in complex with methylated DNA reveal a common recognition mode for 5-methylcytosine (5mC) that involves a 5mC-Arg-G triad. In the two ZnF proteins, an arginine that precedes the first Zn-binding histidine (RH motif) can interact with a 5mCpG or TpG dinucleotide. Among a family of >300 human Krüppel-associat ...[more]
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