Ontology highlight
ABSTRACT:
SUBMITTER: Waltl S
PROVIDER: S-EPMC3610018 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Waltl Sabine S Patankar Jay V JV Fauler Günter G Nusshold Christoph C Ullen Andreas A Eibinger Gerald G Wintersperger Andrea A Kratky Dagmar D Malle Ernst E Sattler Wolfgang W
Neuroscience letters 20130121
Aberrant oxysterol biosynthesis is implicated in the pathogenesis of neurodegenerative diseases. During the present study we have investigated the effects of exogenously added 25-hydroxycholesterol (25-HC) on transcription of cholesterol biosynthetic genes, sterol-regulatory element binding protein (SREBP) processing and cholesterol biosynthesis in the murine CATH.a neuronal cell line. A single i.p. injection of lipopolysaccharide resulted in robust induction of cholesterol 25-hydroxylase mRNA a ...[more]