Ontology highlight
ABSTRACT:
SUBMITTER: Xu M
PROVIDER: S-EPMC3611051 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Xu Ming M Wu Hao-Di HD Li Rong-Chang RC Zhang Hai-Bo HB Wang Meng M Tao Jin J Feng Xin-Heng XH Guo Yun-Bo YB Li Su-Fang SF Lai Shao-Ting ST Zhou Peng P Li Lin-Lin LL Yang Hua-Qian HQ Luo Guan-Zheng GZ Bai Yan Y Xi Jianzhong J JJ Gao Wei W Han Qi-De QD Zhang You-Yi YY Wang Xiu-Jie XJ Meng Xu X Wang Shi-Qiang SQ
Circulation research 20120813 7
<h4>Rationale</h4>Failing cardiomyocytes exhibit decreased efficiency of excitation-contraction (E-C) coupling. The downregulation of junctophilin-2 (JP2), a protein anchoring the sarcoplasmic reticulum to T-tubules, has been identified as a major mechanism underlying the defective E-C coupling. However, the regulatory mechanism of JP2 remains unknown.<h4>Objective</h4>To determine whether microRNAs regulate JP2 expression.<h4>Methods and results</h4>Bioinformatic analysis predicted 2 potential ...[more]