Ontology highlight
ABSTRACT:
SUBMITTER: McKenna DJ
PROVIDER: S-EPMC3865362 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
McKenna Declan J DJ Patel Daksha D McCance Dennis J DJ
Virology 20131029
A screen of microRNA (miRNA) expression following differentiation in human foreskin keratinocytes (HFKs) identified changes in several miRNAs, including miR-24 and miR-205. We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. We demo ...[more]