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Enantioselective total synthesis of plectosphaeroic acid B.

ABSTRACT: The first total synthesis of a member of the plectosphaeroic acid family of fungal natural products is reported. Key steps include the late-stage formation of the hindered N6-C9" bond and stereoselective introduction of the two methylthio substituents.

SUBMITTER: Jabri SY

PROVIDER: S-EPMC3611964 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Enantioselective total synthesis of plectosphaeroic acid B.

Jabri Salman Y SY Overman Larry E LE

Journal of the American Chemical Society 20130306 11

The first total synthesis of a member of the plectosphaeroic acid family of fungal natural products is reported. Key steps include the late-stage formation of the hindered N6-C9" bond and stereoselective introduction of the two methylthio substituents. ...[more]

PMID: 23452064

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