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Nano-encrypted Morse code: a versatile approach to programmable and reversible nanoscale assembly and disassembly.

ABSTRACT: While much work has been devoted to nanoscale assembly of functional materials, selective reversible assembly of components in the nanoscale pattern at selective sites has received much less attention. Exerting such a reversible control of the assembly process will make it possible to fine-tune the functional properties of the assembly and to realize more complex designs. Herein, by taking advantage of different binding affinities of biotin and desthiobiotin toward streptavidin, we demonstrate selective and reversible decoration of DNA origami tiles with streptavidin, including revealing an encrypted Morse code "NANO" and reversible exchange of uppercase letter "I" with lowercase "i". The yields of the conjugations are high (>90%), and the process is reversible. We expect this versatile conjugation technique to be widely applicable with different nanomaterials and templates.

SUBMITTER: Wong NY

PROVIDER: S-EPMC3612397 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Nano-encrypted Morse code: a versatile approach to programmable and reversible nanoscale assembly and disassembly.

Wong Ngo Yin NY Xing Hang H Tan Li Huey LH Lu Yi Y

Journal of the American Chemical Society 20130219 8

While much work has been devoted to nanoscale assembly of functional materials, selective reversible assembly of components in the nanoscale pattern at selective sites has received much less attention. Exerting such a reversible control of the assembly process will make it possible to fine-tune the functional properties of the assembly and to realize more complex designs. Herein, by taking advantage of different binding affinities of biotin and desthiobiotin toward streptavidin, we demonstrate s ...[more]

PMID: 23373425

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