Ontology highlight
ABSTRACT:
SUBMITTER: Shintani Y
PROVIDER: S-EPMC3612600 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Shintani Yasunori Y Kapoor Amar A Kaneko Masahiro M Smolenski Ryszard T RT D'Acquisto Fulvio F Coppen Steven R SR Harada-Shoji Narumi N Lee Hack Jae HJ Thiemermann Christoph C Takashima Seiji S Yashiro Kenta K Suzuki Ken K
Proceedings of the National Academy of Sciences of the United States of America 20130311 13
Toll-like receptors (TLRs) are the central players in innate immunity. In particular, TLR9 initiates inflammatory response by recognizing DNA, imported by infection or released from tissue damage. Inflammation is, however, harmful to terminally differentiated organs, such as the heart and brain, with poor regenerative capacity, yet the role of TLR9 in such nonimmune cells, including cardiomyocytes and neurons, is undefined. Here we uncover an unexpected role of TLR9 in energy metabolism and cell ...[more]