Ontology highlight
ABSTRACT:
SUBMITTER: Alzahrani AM
PROVIDER: S-EPMC3613048 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Alzahrani Abdullah M AM Ragia Georgia G Hanieh Hamza H Manolopoulos Vangelis G VG
BioMed research international 20130317
Polymorphisms in the genes encoding CYP2C9 enzyme and VKORC1 reductase significantly influence the dose variability of coumarinic oral anticoagulants (COAs). Substantial inter- and intraethnic variability exists in the frequencies of CYP2C9*2 and *3 and VKORC1 -1639A alleles. However, the prevalence of CYP2C9 and VKORC1 genetic variants is less characterized in Arab populations. A total of 131 healthy adult subjects from the Al-Ahsa region of Saudi Arabia were genotyped for the CYP2C9 *2 and *3 ...[more]