Ontology highlight
ABSTRACT:
SUBMITTER: Ren H
PROVIDER: S-EPMC3613436 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Ren Hongxia H Orozco Ian J IJ Su Ya Y Suyama Shigetomo S Gutiérrez-Juárez Roger R Horvath Tamas L TL Wardlaw Sharon L SL Plum Leona L Arancio Ottavio O Accili Domenico D
Cell 20120601 6
Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of insulin or leptin signaling in AgRP neurons is predicted to reduce satiety but fails to do so. FoxO1 is a shared mediator of both pathways, and its inhibition is required to induce satiety. Accordingly, FoxO1 ablation in AgRP neurons of mice results in reduced food intake, leanness, improved ...[more]