Ontology highlight
ABSTRACT:
SUBMITTER: Kim JG
PROVIDER: S-EPMC5868421 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Kim Jae Geun JG Sun Ben-Hua BH Dietrich Marcelo O MO Koch Marco M Yao Gang-Qing GQ Diano Sabrina S Insogna Karl K Horvath Tamas L TL
Cell reports 20150924 1
The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic. This phenotype was rescued by cell-selective reactivation of Ucp2 in AgRP neurons. When the AgRP circuitry was impaired by early postnatal deletion of AgRP neurons or ...[more]