Ontology highlight
ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC3613917 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Chen Keqiang K Liu Mingyong M Liu Ying Y Yoshimura Teizo T Shen Wei W Le Yingying Y Durum Scott S Gong Wanghua W Wang Chunyan C Gao Ji-Liang JL Murphy Philip M PM Wang Ji Ming JM
The Journal of clinical investigation 20130401 4
Commensal bacteria and their products provide beneficial effects to the mammalian gut by stimulating epithelial cell turnover and enhancing wound healing, without activating overt inflammation. We hypothesized that N-formylpeptide receptors, which bind bacterial N-formylpeptides and are expressed by intestinal epithelial cells, may contribute to these processes. Here we report that formylpeptide receptor-2 (FPR2), which we show is expressed on the apical and lateral membranes of colonic crypt ep ...[more]