Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi S
PROVIDER: S-EPMC5116627 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Takahashi Sakuma S Yoshimura Teizo T Ohkura Takahiro T Fujisawa Masayoshi M Fushimi Soichiro S Ito Toshihiro T Itakura Junya J Hiraoka Sakiko S Okada Hiroyuki H Yamamoto Kazuhide K Matsukawa Akihiro A
Scientific reports 20161121
Rapid and adequate mucosal healing is important for a remission of ulcerative colitis (UC) patients. Here, we examined whether Spred2, a member of the Sprouty-related EVH1-domain-containing proteins that inhibit the Ras/Raf/ERK pathway, plays a role in colonic mucosal homeostasis and inflammation by using Spred2 knockout (KO) mice. We first detected increased epithelial cell proliferation and cadherin 1 expression in the colon of naïve Spred2 KO mice compared to wild-type mice. Interestingly, Sp ...[more]