Ontology highlight
ABSTRACT:
SUBMITTER: Samanez-Larkin GR
PROVIDER: S-EPMC3615042 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Samanez-Larkin Gregory R GR Buckholtz Joshua W JW Cowan Ronald L RL Woodward Neil D ND Li Rui R Ansari M Sib MS Arrington Catherine M CM Baldwin Ronald M RM Smith Clarence E CE Treadway Michael T MT Kessler Robert M RM Zald David H DH
Biological psychiatry 20121227 2
<h4>Background</h4>Everyday life demands continuous flexibility in thought and behavior. We examined whether individual differences in dopamine function are related to variability in the effects of amphetamine on one aspect of flexibility: task switching.<h4>Methods</h4>Forty healthy human participants performed a task-switching paradigm following placebo and oral amphetamine administration. [(18)F]fallypride was used to measure D2/D3 baseline receptor availability and amphetamine-stimulated dop ...[more]