Ontology highlight
ABSTRACT:
SUBMITTER: Kosillo P
PROVIDER: S-EPMC6882901 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Kosillo Polina P Doig Natalie M NM Ahmed Kamran M KM Agopyan-Miu Alexander H C W AHCW Wong Corinna D CD Conyers Lisa L Threlfell Sarah S Magill Peter J PJ Bateup Helen S HS
Nature communications 20191128 1
Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in TSC1 or TSC2, which encode proteins that negatively regulate mTOR complex 1 (mTORC1). TSC is associated with significant cognitive, psychiatric, and behavioral problems, collectively termed TSC-Associated Neuropsychiatric Disorders (TAND), and the cell types responsible for these manifestations are largely unknown. Here we use cell type-specific Tsc1 deletion to test whether dopamine neurons, which modulate ...[more]