Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3615249 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Zhang Lianghui L Malik Sundeep S Pang Jinjiang J Wang Huan H Park Keigan M KM Yule David I DI Blaxall Burns C BC Smrcka Alan V AV
Cell 20130301 1
Phospholipase Cε (PLCε) is a multifunctional enzyme implicated in cardiovascular, pancreatic, and inflammatory functions. Here we show that conditional deletion of PLCε in mouse cardiac myocytes protects from stress-induced pathological hypertrophy. PLCε small interfering RNA (siRNA) in ventricular myocytes decreases endothelin-1 (ET-1)-dependent elevation of nuclear calcium and activation of nuclear protein kinase D (PKD). PLCε scaffolded to muscle-specific A kinase-anchoring protein (mAKAP), a ...[more]