Ontology highlight
ABSTRACT:
SUBMITTER: Kenny AP
PROVIDER: S-EPMC3615545 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kenny Alan P AP Rankin Scott A SA Allbee Andrew W AW Prewitt Allison R AR Zhang Zheng Z Tabangin Meredith E ME Shifley Emily T ET Louza Mariana P MP Zorn Aaron M AM
Developmental cell 20120802 2
The liver, pancreas, and lungs are induced from endoderm progenitors by a series of dynamic growth factor signals from the mesoderm, but how the temporal-spatial activity of these signals is controlled is poorly understood. We have identified an extracellular regulatory loop required for robust bone morphogenetic protein (BMP) signaling in the Xenopus foregut. We show that BMP signaling is required to maintain foregut progenitors and induce expression of the secreted frizzled related protein Siz ...[more]