Ontology highlight
ABSTRACT:
SUBMITTER: Domyan ET
PROVIDER: S-EPMC4074297 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Domyan Eric T ET Ferretti Elisabetta E Throckmorton Kurt K Mishina Yuji Y Nicolis Silvia K SK Sun Xin X
Development (Cambridge, England) 20110301 5
The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung. Proper patterning and morphogenesis of the common foregut tube and its derived organs is essential for viability of the organism at birth. Here, we show that conditional inactivation of BMP type I receptor genes Bmpr1a and Bmpr1b (Bmpr1a;b) in the ventral endoderm leads to tracheal agenesis and ectopic primary bronchi. Molecular analyses of these mutants reveal a reduction o ...[more]