Ontology highlight
ABSTRACT:
SUBMITTER: DeLuca RJ
PROVIDER: S-EPMC3615722 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
DeLuca Ryan J RJ Edwards Jennifer L JL Steffens Laura D LD Michel Brian W BW Qiao Xiaoxiao X Zhu Chunyin C Cook Silas P SP Sigman Matthew S MS
The Journal of organic chemistry 20130206 4
The Pd-catalyzed TBHP-mediated Wacker-type oxidation of internal alkenes is reported. The reaction uses 2-(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to deliver single ketone constitutional isomer products in a predictable fashion from electronically biased olefins. This methodology is showcased through its application on an advanced intermediate in the total synthesis of the antimalarial drug artemisinin. ...[more]