Ontology highlight
ABSTRACT:
SUBMITTER: Liu XJ
PROVIDER: S-EPMC3616027 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Liu Xue Jun XJ Gingrich Jeffrey R JR Vargas-Caballero Mariana M Dong Yi Na YN Sengar Ameet A Beggs Simon S Wang Szu-Han SH Ding Hoi Ki HK Frankland Paul W PW Salter Michael W MW
Nature medicine 20081116 12
Chronic pain hypersensitivity depends on N-methyl-D-aspartate receptors (NMDARs). However, clinical use of NMDAR blockers is limited by side effects resulting from suppression of the physiological functions of these receptors. Here we report a means to suppress pain hypersensitivity without blocking NMDARs, but rather by inhibiting the binding of a key enhancer of NMDAR function, the protein tyrosine kinase Src. We show that a peptide consisting of amino acids 40-49 of Src fused to the protein t ...[more]