Ontology highlight
ABSTRACT:
SUBMITTER: Waites CL
PROVIDER: S-EPMC3616282 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Waites Clarissa L CL Leal-Ortiz Sergio A SA Okerlund Nathan N Dalke Hannah H Fejtova Anna A Altrock Wilko D WD Gundelfinger Eckart D ED Garner Craig C CC
The EMBO journal 20130212 7
The presynaptic active zone (AZ) is a specialized microdomain designed for the efficient and repetitive release of neurotransmitter. Bassoon and Piccolo are two high molecular weight components of the AZ, with hypothesized roles in its assembly and structural maintenance. However, glutamatergic synapses lacking either protein exhibit relatively minor defects, presumably due to their significant functional redundancy. In the present study, we have used interference RNAs to eliminate both proteins ...[more]