Degradation of activated protein kinases by ubiquitination.
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ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC2776765 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Degradation of activated protein kinases by ubiquitination.
Annual review of biochemistry 20090101
Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases. ...[more]
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