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Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.

ABSTRACT: As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC3616611 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.

Zhang Zijuan Z Kwiatkowski Nicholas N Zeng Hong H Lim Sang Min SM Gray Nathanael S NS Zhang Wei W Yang Priscilla L PL

Molecular bioSystems 20121001 10

As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy. ...[more]

PMID: 22673640

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