Isodicentric Y chromosomes and sex disorders as byproducts of homologous recombination that maintains palindromes.
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ABSTRACT:
SUBMITTER: Lange J
PROVIDER: S-EPMC3616640 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Isodicentric Y chromosomes and sex disorders as byproducts of homologous recombination that maintains palindromes.
Lange Julian J Skaletsky Helen H van Daalen Saskia K M SK Embry Stephanie L SL Korver Cindy M CM Brown Laura G LG Oates Robert D RD Silber Sherman S Repping Sjoerd S Page David C DC
Cell 20090901 5
Massive palindromes in the human Y chromosome harbor mirror-image gene pairs essential for spermatogenesis. During evolution, these gene pairs have been maintained by intrapalindrome, arm-to-arm recombination. The mechanism of intrapalindrome recombination and risk of harmful effects are unknown. We report 51 patients with isodicentric Y (idicY) chromosomes formed by homologous crossing over between opposing arms of palindromes on sister chromatids. These ectopic recombination events occur at ne ...[more]
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