Ontology highlight
ABSTRACT:
SUBMITTER: Yan J
PROVIDER: S-EPMC3616747 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Yan Jun J Chen Xi X Wang Fengshan F Cao Hongzhi H
Organic & biomolecular chemistry 20121214 5
Fluorinated Thomsen-Friedenreich (T) antigens were synthesized efficiently from chemically produced fluorinated monosaccharides using a highly efficient one-pot two-enzyme chemoenzymatic approach containing a galactokinase and a D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase. These fluorinated T-antigens were further sialylated to form fluorinated ST-antigens using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α-2-3-sialyltransferase. ...[more]