Unknown

Dataset Information

0

Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms.


ABSTRACT: Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-?1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an ?2-3-sialyltransferase or an ?2-6-sialyltransferase.

SUBMITTER: Li L 

PROVIDER: S-EPMC4498953 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3201767 | biostudies-literature
| S-EPMC3616747 | biostudies-literature
| S-EPMC3115702 | biostudies-literature
| S-EPMC9931048 | biostudies-literature
| S-EPMC6010273 | biostudies-literature
| S-EPMC2652316 | biostudies-literature
| S-EPMC2075035 | biostudies-literature
| S-EPMC5396139 | biostudies-literature
| S-EPMC6017136 | biostudies-literature
| S-EPMC6017073 | biostudies-literature