Phosphodiesterase 4-targeted treatments for autoimmune diseases.
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ABSTRACT:
SUBMITTER: Kumar N
PROVIDER: S-EPMC3616808 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Phosphodiesterase 4-targeted treatments for autoimmune diseases.
Kumar Neal N Goldminz Ari M AM Kim Noori N Gottlieb Alice B AB
BMC medicine 20130404
Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibitors and the associated literature with a focus on treatments for autoimmune diseases. After the initial investigations of the prototypic PDE inhibitor, rolipram, more selective inhibitors targeting the PDE4 isozyme have been developed. With phase II and phase III clinical trials currently u ...[more]
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