Ontology highlight
ABSTRACT:
SUBMITTER: Tchurikov NA
PROVIDER: S-EPMC3616924 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Tchurikov Nickolai A NA Kretova Olga V OV Fedoseeva Daria M DM Sosin Dmitri V DV Grachev Sergei A SA Serebraykova Marina V MV Romanenko Svetlana A SA Vorobieva Nadezhda V NV Kravatsky Yuri V YV
PLoS genetics 20130404 4
Genome instability plays a key role in multiple biological processes and diseases, including cancer. Genome-wide mapping of DNA double-strand breaks (DSBs) is important for understanding both chromosomal architecture and specific chromosomal regions at DSBs. We developed a method for precise genome-wide mapping of blunt-ended DSBs in human chromosomes, and observed non-random fragmentation and DSB hot spots. These hot spots are scattered along chromosomes and delimit protected 50-250 kb DNA doma ...[more]