Ontology highlight
ABSTRACT:
SUBMITTER: Dorier J
PROVIDER: S-EPMC3737558 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Nucleic acids research 20130605 14
Using numerical simulations of pairs of long polymeric chains confined in microscopic cylinders, we investigate consequences of double-strand DNA breaks occurring in independent topological domains, such as these constituting bacterial chromosomes. Our simulations show a transition between segregated and mixed state upon linearization of one of the modelled topological domains. Our results explain how chromosomal organization into topological domains can fulfil two opposite conditions: (i) effec ...[more]