Ontology highlight
ABSTRACT:
SUBMITTER: Mori S
PROVIDER: S-EPMC3617051 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Mori Seiichi S Rempel Rachel E RE Chang Jeffrey T JT Yao Guang G Lagoo Anand S AS Potti Anil A Bild Andrea A Nevins Joseph R JR
Cancer research 20081001 20
The Emu-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the Emu-myc mice associated with time of tumor onset. Furthermore, one form of Emu-myc tumor with pre-B character is shown to resemble human Burkitt lymphoma, whereas others exhibit more differentiated B-cell characteristi ...[more]