Ontology highlight
ABSTRACT:
SUBMITTER: Davies AJ
PROVIDER: S-EPMC2532951 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Davies Andrew J AJ Rosenwald Andreas A Wright George G Lee Abigail A Last Kim W KW Weisenburger Dennis D DD Chan Wing C WC Delabie Jan J Braziel Rita M RM Campo Elias E Gascoyne Randy D RD Jaffe Elaine S ES Muller-Hermelink Konrad K Ott German G Calaminici Maria M Norton Andrew J AJ Goff Lindsey K LK Fitzgibbon Jude J Staudt Louis M LM Andrew Lister T T
British journal of haematology 20070101 2
This study was undertaken to further elucidate the biological mechanisms underlying the frequent event of transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL). The gene expression profiles of 20 paired lymph node biopsies, derived from the same patient pre- and post-transformation, were analysed using the Lymphochip cDNA microarray. TP53 mutation analysis was performed and copy number alterations at the c-REL and CDNK2A examined. Immunohistochemistry was performed o ...[more]