Ontology highlight
ABSTRACT:
SUBMITTER: Ikram MA
PROVIDER: S-EPMC3618290 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Ikram M Arfan MA Fornage Myriam M Smith Albert V AV Seshadri Sudha S Schmidt Reinhold R Debette Stéphanie S Vrooman Henri A HA Sigurdsson Sigurdur S Ropele Stefan S Taal H Rob HR Mook-Kanamori Dennis O DO Coker Laura H LH Longstreth W T WT Niessen Wiro J WJ DeStefano Anita L AL Beiser Alexa A Zijdenbos Alex P AP Struchalin Maksim M Jack Clifford R CR Rivadeneira Fernando F Uitterlinden Andre G AG Knopman David S DS Hartikainen Anna-Liisa AL Pennell Craig E CE Thiering Elisabeth E Steegers Eric A P EA Hakonarson Hakon H Heinrich Joachim J Palmer Lyle J LJ Jarvelin Marjo-Riitta MR McCarthy Mark I MI Grant Struan F A SF St Pourcain Beate B Timpson Nicholas J NJ Smith George Davey GD Sovio Ulla U Nalls Mike A MA Au Rhoda R Hofman Albert A Gudnason Haukur H van der Lugt Aad A Harris Tamara B TB Meeks William M WM Vernooij Meike W MW van Buchem Mark A MA Catellier Diane D Jaddoe Vincent W V VW Gudnason Vilmundur V Windham B Gwen BG Wolf Philip A PA van Duijn Cornelia M CM Mosley Thomas H TH Schmidt Helena H Launer Lenore J LJ Breteler Monique M B MM DeCarli Charles C
Nature genetics 20120415 5
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10(-8)) for brain volume. In contrast, intracranial volume was significa ...[more]