Ontology highlight
ABSTRACT:
SUBMITTER: Geier EG
PROVIDER: S-EPMC3619328 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Geier Ethan G EG Schlessinger Avner A Fan Hao H Gable Jonathan E JE Irwin John J JJ Sali Andrej A Giacomini Kathleen M KM
Proceedings of the National Academy of Sciences of the United States of America 20130318 14
The Large-neutral Amino Acid Transporter 1 (LAT-1)--a sodium-independent exchanger of amino acids, thyroid hormones, and prescription drugs--is highly expressed in the blood-brain barrier and various types of cancer. LAT-1 plays an important role in cancer development as well as in mediating drug and nutrient delivery across the blood-brain barrier, making it a key drug target. Here, we identify four LAT-1 ligands, including one chemically novel substrate, by comparative modeling, virtual screen ...[more]