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Growth Inhibitory Activity of a Bis-benzimidazole-Bridged Arene Ruthenium Metalla-Rectangle and Prism.

ABSTRACT: Two new supramolecular coordination complexes (SCCs), were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, 4, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism 6 selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC50 values as low as 8.41 ?M for MCF7 cells, as determined from MTS assays.

SUBMITTER: Vajpayee V

PROVIDER: S-EPMC3619444 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Growth Inhibitory Activity of a Bis-benzimidazole-Bridged Arene Ruthenium Metalla-Rectangle and Prism.

Vajpayee Vaishali V Lee Sun Mi SM Park Joeng Woo JW Dubey Abhishek A Kim Hyunuk H Cook Timothy R TR Stang Peter J PJ Chi Ki-Whan KW

Organometallics 20130301 6

Two new supramolecular coordination complexes (SCCs), were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, 4, with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism 6 selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC50 values as low as 8.41 μM for MCF7 cells, as determined from MTS assays. ...[more]

PMID: 23580795

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