Amikacin-induced Fin Reduction is Mediated by Autophagy.
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ABSTRACT:
SUBMITTER: Tsai IT
PROVIDER: S-EPMC3620219 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Amikacin-induced Fin Reduction is Mediated by Autophagy.
Tsai I-Ting IT Chen Ying-Hsin YH Chen Yau-Hung YH Wang Yun-Hsin YH
Journal of toxicologic pathology 20130301 1
Despite its medical use, little is known about the mechanisms underlying amikacin-induced embryotoxicity, including fin reduction, in zebrafish. In this study, we examined the expression of well-known autophagy markers mTOR (target of rapamycin), atg10 (autophagy-related gene), atg12 and LC3 (mammalian homolog of Atg8) in amikacin-treated zebrafish embryos. Our results indicated that the mRNA expression level of atg12 in the amikacin-treated group was significantly increased by 1.5-fold (p<0.05) ...[more]
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