Ontology highlight
ABSTRACT:
SUBMITTER: McGuire AT
PROVIDER: S-EPMC3620356 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
McGuire Andrew T AT Hoot Sam S Dreyer Anita M AM Lippy Adriana A Stuart Andrew A Cohen Kristen W KW Jardine Joseph J Menis Sergey S Scheid Johannes F JF West Anthony P AP Schief William R WR Stamatatos Leonidas L
The Journal of experimental medicine 20130325 4
Broadly neutralizing antibodies (bnAbs) against HIV are believed to be a critical component of the protective responses elicited by an effective HIV vaccine. Neutralizing antibodies against the evolutionarily conserved CD4-binding site (CD4-BS) on the HIV envelope glycoprotein (Env) are capable of inhibiting infection of diverse HIV strains, and have been isolated from HIV-infected individuals. Despite the presence of anti-CD4-BS broadly neutralizing antibody (bnAb) epitopes on recombinant Env, ...[more]