Ontology highlight
ABSTRACT:
SUBMITTER: Hundhausen C
PROVIDER: S-EPMC3620929 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Hundhausen Christian C Bertoni Anna A Mak Rose K RK Botti Elisabetta E Di Meglio Paola P Clop Alex A Laggner Ute U Chimenti Sergio S Hayday Adrian C AC Barker Jonathan N JN Trembath Richard C RC Capon Francesca F Nestle Frank O FO
The Journal of investigative dermatology 20111124 3 Pt 1
Psoriasis is an inflammatory skin disorder that is inherited as a complex trait. Genetic studies have repeatedly highlighted HLA-C as the major determinant for psoriasis susceptibility, with the Cw*0602 allele conferring significant disease risk in a wide range of populations. Despite the potential importance of HLA-C variation in psoriasis, either via an effect on peptide presentation or immuno-inhibitory activity, allele-specific expression patterns have not been investigated. Here, we used re ...[more]