Ontology highlight
ABSTRACT:
SUBMITTER: Bentebibel SE
PROVIDER: S-EPMC3621097 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Bentebibel Salah-Eddine SE Lopez Santiago S Obermoser Gerlinde G Schmitt Nathalie N Mueller Cynthia C Harrod Carson C Flano Emilio E Mejias Asuncion A Albrecht Randy A RA Blankenship Derek D Xu Hui H Pascual Virginia V Banchereau Jacques J Garcia-Sastre Adolfo A Palucka Anna Karolina AK Ramilo Octavio O Ueno Hideki H
Science translational medicine 20130301 176
Seasonal influenza vaccine protects 60 to 90% of healthy young adults from influenza infection. The immunological events that lead to the induction of protective antibody responses remain poorly understood in humans. We identified the type of CD4+ T cells associated with protective antibody responses after seasonal influenza vaccinations. The administration of trivalent split-virus influenza vaccines induced a temporary increase of CD4+ T cells expressing ICOS, which peaked at day 7, as did plas ...[more]