Ontology highlight
ABSTRACT:
SUBMITTER: Chen XW
PROVIDER: S-EPMC3622177 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
eLife 20130409
The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi. We now report that complete genetic deficiency for the COPII component SEC24A is compatible with normal survival and development in the mouse, despite the fundamental role of SEC24 in COPII vesicle formation and cargo recruitment. However, these animals exhibit markedly reduced plasma cholesterol, with mutations in Apoe and Ldlr epistatic to ...[more]