Ontology highlight
ABSTRACT:
SUBMITTER: Freudiger CW
PROVIDER: S-EPMC3622202 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Freudiger Christian W CW Pfannl Rolf R Orringer Daniel A DA Saar Brian G BG Ji Minbiao M Zeng Qing Q Ottoboni Linda L Wei Ying Y Waeber Christian C Sims John R JR De Jager Philip L PL Sagher Oren O Philbert Martin A MA Xu Xiaoyin X Kesari Santosh S Xie X Sunney XS Young Geoffrey S GS
Laboratory investigation; a journal of technical methods and pathology 20120820 10
Conventional histopathology with hematoxylin & eosin (H&E) has been the gold standard for histopathological diagnosis of a wide range of diseases. However, it is not performed in vivo and requires thin tissue sections obtained after tissue biopsy, which carries risk, particularly in the central nervous system. Here we describe the development of an alternative, multicolored way to visualize tissue in real-time through the use of coherent Raman imaging (CRI), without the use of dyes. CRI relies o ...[more]