Ontology highlight
ABSTRACT:
SUBMITTER: Chalamalasetty RB
PROVIDER: S-EPMC3622708 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Chalamalasetty Ravindra B RB Dunty William C WC Biris Kristin K KK Ajima Rieko R Iacovino Michelina M Beisaw Arica A Feigenbaum Lionel L Chapman Deborah L DL Yoon Jeong Kyo JK Kyba Michael M Yamaguchi Terry P TP
Nature communications 20110712
Segmentation is an organizing principle of body plans. The segmentation clock, a molecular oscillator best illustrated by the cyclic expression of Notch signalling genes, controls the periodic cleavage of somites from unsegmented presomitic mesoderm during vertebrate segmentation. Wnt3a controls the spatiotemporal expression of cyclic Notch genes; however, the underlying mechanisms remain obscure. Here we show by transcriptional profiling of Wnt3a (-/-) embryos that the bHLH transcription factor ...[more]