Ontology highlight
ABSTRACT:
SUBMITTER: Gibb S
PROVIDER: S-EPMC2686089 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Gibb Sarah S Zagorska Anna A Melton Kristin K Tenin Gennady G Vacca Irene I Trainor Paul P Maroto Miguel M Dale J Kim JK
Developmental biology 20090306 1
Somites are embryonic precursors of the ribs, vertebrae and certain dermis tissue. Somite formation is a periodic process regulated by a molecular clock which drives cyclic expression of a number of clock genes in the presomitic mesoderm. To date the mechanism regulating the period of clock gene oscillations is unknown. Here we show that chick homologues of the Wnt pathway genes that oscillate in mouse do not cycle across the chick presomitic mesoderm. Strikingly we find that modifying Wnt signa ...[more]