Ontology highlight
ABSTRACT:
SUBMITTER: Pera M
PROVIDER: S-EPMC3623032 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Pera Marta M Alcolea Daniel D Sánchez-Valle Raquel R Guardia-Laguarta Cristina C Colom-Cadena Martí M Badiola Nahuai N Suárez-Calvet Marc M Lladó Albert A Barrera-Ocampo Alvaro A AA Sepulveda-Falla Diego D Blesa Rafael R Molinuevo José L JL Clarimón Jordi J Ferrer Isidre I Gelpi Ellen E Lleó Alberto A
Acta neuropathologica 20121206 2
Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-modifying therapies in sporadic AD (SAD). However, whether the pathological changes in APP processing in the CNS in ADAD are similar to those observed in SAD remains un ...[more]