Ontology highlight
ABSTRACT:
SUBMITTER: Chhatwal JP
PROVIDER: S-EPMC3776464 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chhatwal Jasmeer P JP Schultz Aaron P AP Johnson Keith K Benzinger Tammie L S TL Jack Clifford C Ances Beau M BM Sullivan Caroline A CA Salloway Stephen P SP Ringman John M JM Koeppe Robert A RA Marcus Daniel S DS Thompson Paul P Saykin Andrew J AJ Correia Stephen S Schofield Peter R PR Rowe Christopher C CC Fox Nick C NC Brickman Adam M AM Mayeux Richard R McDade Eric E Bateman Randall R Fagan Anne M AM Goate Allison M AM Xiong Chengjie C Buckles Virginia D VD Morris John C JC Sperling Reisa A RA
Neurology 20130724 8
<h4>Objective</h4>To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network.<h4>Methods</h4>Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, ...[more]